Chemistry!

Chemistry in the body is so important. Different atomic structures will lead to different ways molecules interact with one another. Spermidine is highly polycationic which means it carries multiple positive charges, making it more prone to interact with negatively charged molecules (Pegg, 2011). Your DNA has major and minor grooves that spermidine can bind onto (Greger, 2023, p. 29). Spermidine helps ensure proper DNA translation by latching onto genetic material (Greger, 2023, p. 29). In fact, most spermidine is bound to genetic material (Greger, 2023, p. 29). There are two primary amino groups on a spermidine molecule and one secondary amino group (Wolff et al., 1995). I know, I know, this must be a lot of new information. To help give some comparison it is good to know that protein molecules also contain amino groups. These amino groups accept protons quickly so they are responsible for why the molecule is very positively charged (⁠Liang, Guan, & Liu, 2022⁠).